Cape Town glistens at the southern toe of the African continent. Tourist brochure-views at Blaauwberg Beach and Kirstenbosch National Botanical Gardens are within easy driving distance of "The Mother City." The Cape of Good Hope Nature Reserve provides sweeping sea vistas, hiking trails and wildlife encounters. On a more somber note, travelers can visit Robben Island, the prison where Nelson Mandela was held for 27 years. 
City slickers, culture vultures and beach bums alike fall in love with Sydney. Hang ten at famed Bondi Beach or stroll the calmer sands of Coogee. Cash burning a hole in your pocket? You’ll find great shopping in the Rocks district and along George and Pitt Streets. Climb to the top of the Harbour Bridge or take a skywalk on Sydney Tower for a 360-degree view of the city. But whatever you do, don’t leave town without cuddling the koalas in the Taronga Park Zoo—they’re ridiculously adorable.
It's no wonder Machu Picchu is Peru's most-visited site. Dating to the mid-1400s, it's a marvel of mortar-free limestone architecture perched on a high plateau deep in the Amazonian jungle. Get there via train from Cusco or, if you're not faint-hearted, make the trip on foot via a multi-day hiking trail—you'll travel through deep Andean gullies and enjoy stunning views. 4. Paris, France
Everyone who visits Paris for the first time probably has the same punchlist of major attractions to hit: The Louvre, Notre Dame, The Eiffel Tower, etc. Just make sure you leave some time to wander the city’s grand boulevards and eat in as many cafes, bistros and brasseries as possible. And don’t forget the shopping—whether your tastes run to Louis Vuitton or Les Puces (the flea market), you can find it here. 5. Rio de Janeiro, Brazil
Whether your curiosity is piqued by the International Olympic Committee’s selection for the 2016 Games, or you’re heeding the call of the famous twin beaches Copacabana and Ipanema, Rio offers more than you can imagine, and offers it at all hours. With breathtaking views from Corcovado Mountain and breathtaking deals in the city’s endless malls and markets, Rio de Janeiro is a vacation paradise, whatever it is you travel for. 6. New York City, New York
The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighborhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveler. 7. Rome, Italy
It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita? 8. London, United Kingdom
There's so much to see and do in London, it's easy to be overwhelmed. Major sights like the Tower of London and Buckingham Palace are on most visitors' itineraries, but no matter what your interests, you'll probably find something here. Art lovers should make a beeline for the National Gallery and the Tate Modern. If military history's your thing, don't miss the Cabinet War Rooms. Finally, forget everything you've heard about bland, mushy British food—the restaurant scene here is fabulous.9. Barcelona, Spain
Stroll Las Ramblas and enjoy Barcelona's unique blend of Catalan culture, distinctive architecture, lively nightlife and trendy, stylish hotels. You'll find Europe's best-preserved Gothic Quarter here, as well as amazing architectural works by Gaudi. La Sagrada Familia, considered Gaudi's masterpiece, is still under construction (your entrance fee helps to fund the project). Feel like a picnic? Look no further than the rambunctious La Boqueria market, where you can stock up on local delicacies. 10. Hong Kong, China
Hong Kong's a great city for an adventurous eater. Stop at a street vendor for fish balls on a stick or stinky tofu. Bakeries offer wife cake, pineapple buns and egg tarts. Or opt for as much dim sum as you can eat. If you're tired of local and regional Chinese specialties, check out upscale offerings from some of the world's top chefs, like Joel Robouchon and Alain Ducasse.11. Kyoto, Japan
Regardless of season, it's hard not to succumb to romance as you wander Kyoto's atmospheric streets, gaze at the glimmering Kinkaku-ji Pavilion, enjoy the traditional dances of the geisha or feast at restaurants over the Kamo River. Only Rome has more World Heritage Sites than the former Japanese capital. But happily unlike Rome, Kyoto maintains its calmness and romance even among throngs of summer tourists. (Editor's note: Our list was compiled before Japan's devastating earthquake of March 11, 2011. Kyoto did not sustain major damage, but we encourage all travelers to Japan to monitor travel alerts from their government.) 12. Queenstown, New Zealand
Staggering beauty and heart-pumping thrills await in the resort town of Queenstown, which is also known for its Hobbits—much of the Lord of the Rings trilogy was filmed in the area. Outdoor enthusiasts flock to Queenstown for the kayaking, bungee jumping, jetboating, white-water rafting, hiking and skiing. More mild-mannered adventurers can take a quiet cruise through nearby Milford Sound, part of the Fjordland National Park World Heritage area, or sample South Island pinot noir from one of the region's 75 wineries. 13. Jerusalem, Israel
Religious pilgrims have been traveling to Jerusalem for centuries, yet you don’t have to share their zeal in order to appreciate this city’s profound cultural and historical significance. Plan on seeing the major sights, but also leave plenty of time to walk through the streets and simply immerse yourself in the daily life of such an ancient and revered place. 14. Siem Reap, Cambodia
Siem Reap is a fast-growing city with plenty of new hotels, restaurants and nightclubs. But chances are, you’re here not because of the city itself, but for what’s nearby: amazingly well-preserved ancient temples. Even if you have the worst jet lag ever, drag yourself out of bed to be at Angkor Archeological Park when it opens—sunrise over Angkor Wat is worth losing sleep over. 15. Prague, Czech Republic
We hear the question, "What’s the next Prague?" a lot. But while we’re all for discovering great new destinations, we hardly think Prague is over. Sure, everyone’s heard of it, but it’s still a grand city with extraordinary historic and cultural sights, and it’s definitely worth a visit. The often-rebuilt Prague Castle has overlooked the city since the 9th century, and the synagogues and cemetery of the Jewish Quarter are must-sees. Nightlife here is diverse and plentiful, from trendy clubs to sophisticated wine bars to late-night cellar bars.16. Venice, Italy
Stunning architecture. Mysterious passageways. And of course, the canals. Venice is one of the most alluring cities in the world—the type of place where, as a visitor, you'll welcome getting lost (as you inevitably will). Relax in Piazza San Marco, take a moonlit gondola ride or taste the original Bellini at Harry's Bar. Or just wander. No matter where you go, you'll find history, beauty and romance.17. Buenos Aires, Argentina
The birthplace of the tango is, like the dance itself, captivating, seductive and bustling with excited energy. Atmospheric old neighborhoods are rife with romantic restaurants and thumping nightlife, and Buenos Aires' European heritage is evident in its architecture, boulevards and parks. Cafe Tortoni, the city's oldest bar, will transport you back to 1858, and the spectacular Teatro Colon impresses just as it did in 1908. Latin America's shopping capital offers the promise of premium retail therapy along its grand, wide boulevards.18. Ko Phi Phi Don, Thailand
Most of this limestone island is a protected marine reserve… which means you’ll enjoy unspoiled beaches, as well as fantastic diving and snorkeling. Several local dive shops get great reviews from our travelers. When you’re back on dry land, chill out even more with a session of yoga on the beach.19. Honolulu, Hawaii
Honolulu is a legendary surfing destination. But even if you don’t know a boogie board from a surfboard, you’ll find a beach here that appeals to you (and, if you want to learn the difference, you can find a great instructor to teach you). Swimming, kayaking, snorkeling, outrigger canoeing or just sunbathing… it’s all available in Honolulu.20. St. Petersburg, Russia
The second largest city in Russia, St. Petersburg is the country’s cultural heart. View splendid architectural gems like the Winter Palace and the Kazan Cathedral, and give yourself plenty of time to browse the world-renowned art collection of the Hermitage. Sprawling across the Neva River delta, St. Petersburg offers enough art, nightlife, fine dining and cultural destinations for many repeat visits. 21. Florence, Italy
Everyone’s heard the Doors of Paradise, the Duomo, and Michelangelo’s David are captivating, but in Florence, beauty can sneak up on a traveler unexpectedly. You’ll duck into a random church to escape the heat only to spend two hours staring at an impossibly pure blue in a fresco. Or you’ll consider writing a sonnet about pear gelato. It’s just that kind of place. Don't miss the sunset over the Arno and the famous wines of the Chianti region just south of town. 22. Grand Cayman
The farther you go from Grand Cayman's busy docks, the more peace and quiet you'll find. At Stingray City (actually a sandbar), stingrays swim alongside you in the tranquil waters. Closer to town, travelers report finding some of the best massage and spa services anywhere in the Caribbean. 23. San Francisco, California
Who cares about a little fog (okay, a lot of fog) when there’s so much to do in San Francisco? By day, explore Fisherman’s Wharf and the Aquarium of the Bay, ride a cable car, and stroll around the Presidio; by night, have a fabulous dinner (at a Michelin-starred restaurant or a tiny place in Chinatown), then hit some of the best clubs on the West Coast.24. Petra / Wadi Musa, Jordan
Petra, a UNESCO World Heritage Site, is one of the New Seven Wonders of the World. Travelers have fascinating places to explore here, including the breathtaking 2,000-year-old Treasury, the narrow Siq gorge (the main entrance to Petra), and the High Place of Sacrifice.25. Las Vegas, Nevada
In Las Vegas, you’ll find restaurants run by the world’s finest chefs, opulent spas, and sophisticated hotels… along with penny slots, Elvis impersonators, and indoor Venetian canals (complete with gondoliers). Why come here? Because there is simply no other place on the planet like Las Vegas. And we wouldn’t have it any other way.
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